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Afatinib Dimaleate and Food

Result of checking the interaction of Afatinib Dimaleate and Food for safety when used together.

Check result:

Afatinib Dimaleate <> Food

Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Food may reduce the absorption of afatinib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take afatinib at least 1 hour before or 2 hours after a meal.

Professional:

ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of afatinib. According to the product labeling, administration of afatinib with a high-fat meal decreased peak plasma concentration (Cmax) by 50% and systemic exposure (AUC) by 39% compared to administration in the fasted state.

MANAGEMENT: Afatinib should be taken at least 1 hour before or 2 hours after a meal.

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