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Disulfiram and Caffeine

Result of checking the interaction of Disulfiram and Caffeine for safety when used together.

Check result:

Disulfiram <> Caffeine

Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Disulfiram may increase the cardiovascular and CNS-stimulant effects of caffeine. The mechanism may be related to inhibition of caffeine metabolism in liver microsomes. Patients should be advised to limit their caffeine intake while they are taking disulfiram, particularly if they are experiencing excessive irritability, nervousness or insomnia.

References:

Beach CA, Mays DC, Guiler RC, et al "Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics." Clin Pharmacol Ther 39 (1986): 265-70

Disulfiram

Generic Name: disulfiram

Brand Name: Antabuse

Synonyms: n.a.

What is Disulfiram?