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Nintedanib Esylate and Food

Result of checking the interaction of Nintedanib Esylate and Food for safety when used together.

Check result:

Nintedanib Esylate <> Food

Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Food may help the absorption of nintedanib. You should take this medication with food and swallow it whole with liquid. Chewing or crushing the medication can leave a bitter taste.

Professional:

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of nintedanib. After food intake, nintedanib exposure increased by approximately 20% compared to administration under fasted conditions. Absorption was also delayed, as indicated by an increase in the median time to reach maximum plasma concentration (Tmax) from 2 hours in the fasted state to approximately 4 hours under fed conditions, irrespective of the type of food ingested.

MANAGEMENT: Nintedanib should be administered with food.

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