Cedax (Ceftibuten Capsules) and Food

The following interaction applies only if you are taking ceftibuten (brand name Cedax) in the liquid formulation: Food may reduce the absorption of ceftibuten from the liquid (suspension) formulation, which may lead to lower blood levels of the medication and possibly reduced effectiveness. Therefore, it should be taken on an empty stomach at least two hours before or one hour after a meal. If you are taking the capsule formulation, you may take it with or without food. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Food reduces the oral absorption and bioavailability of ceftibuten. According to the product labeling, administration of ceftibuten oral suspension with a high-fat breakfast decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 26% and 17%, respectively. Administration of ceftibuten capsules with a standardized breakfast decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 18% and 8%, respectively.

MANAGEMENT: To ensure maximal oral absorption, ceftibuten oral suspension should be taken at least two hours before or one hour after a meal.