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Cefpodoxime and Food

Result of checking the interaction of Cefpodoxime and Food for safety when used together.

Check result:

Cefpodoxime <> Food

Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Food can enhance the levels of cefpodoxime tablets in your body. Take the cefpodoxime tablets with food to increase absorption by the body. The cefpodoxime suspension can be taken with or without food. You should take cefpodoxime at the same time each day.

Professional:

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of cefpodoxime proxetil tablets. Following a 200 mg dose taken with food, the extent of absorption (mean AUC) was 21% to 33% higher and the mean peak plasma concentration (Cmax) 19% higher than under fasting conditions. Time to peak concentration (Tmax) was not significantly different between fed and fasted states. On the contrary, when a 200 mg dose of the suspension was taken with food, the mean AUC and Cmax were not significantly different than those under fasting conditions, although the rate of absorption was slower with food (48% increase in Tmax ).

MANAGEMENT: To ensure maximal oral absorption, cefpodoxime proxetil tablets should be administered with or immediately after a meal.

References:

Borin MT, Driver MR, Forbes KK "Effect of timing of food on absorption of cefpodoxime proxetil." J Clin Pharmacol 35 (1995): 505-9
Hughes GS, Heald DL, Barker KB, et al "The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil." Clin Pharmacol Ther 46 (1989): 674-85
"Product Information. Vantin (cefpodoxime proxetil)." Pharmacia and Upjohn, Kalamazoo, MI.

Cefpodoxime

Generic Name: cefpodoxime

Brand Name: Vantin

Synonyms: n.a.

What is Cefpodoxime?