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Erlotinib and Food

Result of checking the interaction of Erlotinib and Food for safety when used together.

Check result:

Erlotinib <> Food

Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Erlotinib should be taken on an empty stomach 1 hour before or 2 hours after a meal and at the same time each day unless otherwise directed by your doctor. You should also avoid grapefruit and grapefruit juice while taking erlotinib. Food and grapefruit can raise the levels of erlotinib in your body and lead to increased side effects. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Professional:

GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of erlotinib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits.

ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of erlotinib. According to product labeling, administration with food increased the oral bioavailability of erlotinib from approximately 60% to almost 100% compared to administration in the fasting state.

MANAGEMENT: Patients treated with erlotinib should preferably avoid consumption of grapefruit or grapefruit juice. Erlotinib should be administered at least one hour before or two hours after the ingestion of food.

References:

Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7
"Product Information. Tarceva (erlotinib)." Genentech, South San Francisco, CA.

Erlotinib

Generic Name: erlotinib

Brand Name: Tarceva

Synonyms: n.a.

What is Erlotinib?