Esomeprazole Magnesium and Obesity

• Generic Name: esomeprazole
• Dosage Forms: n.a.
• Other Brand Names: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV

Short-term treatment of symptomatic GERD (e.g., heartburn) in patients without erosive esophagitis.

Short-term treatment of erosive esophagitis (diagnostically confirmed) in patients with GERD. Short-term treatment of erosive esophagitis due to acid-mediated GERD in infants.

Maintain healing, symptom resolution, and decrease recurrence of erosive esophagitis.

IV as short-term alternative to oral therapy in patients with erosive esophagitis who are unable to take the drug orally; safety and efficacy not established beyond 10 days.

Treatment of Helicobacter pylori infection and duodenal ulcer disease (active duodenal ulcer or history of duodenal ulcer in the past 5 years). Used in conjunction with amoxicillin and clarithromycin (triple therapy).

Reduction in the occurrence of gastric ulcers associated with chronic NSAIA therapy in patients at risk (i.e., ≥60 years of age and/or history of gastric ulcer). Effect on occurrence of duodenal ulcers not established.

Some evidence for use of proton-pump inhibitors (e.g., omeprazole) for gastric acid suppressive therapy as an adjunct in the management of upper GI Crohn’s disease, including esophageal, gastroduodenal, and jejunoileal disease.