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Galafold and Food

Result of checking the interaction of Galafold and Food for safety when used together.

Check result:

Galafold <> Food

Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Food reduces the absorption of migalastat into the bloodstream, which may make the medication less effective in treating your condition. You should avoid eating for at least 2 hours before and 2 hours after taking migalastat. Clear liquids may be consumed during this 4 hour period when you cannot eat.

Professional:

ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of migalastat. When migalastat was administered one hour before a high-fat (850 calories; 56% from fat) or light meal (507 calories; 30% from fat), or one hour after a light meal, mean migalastat peak plasma concentration (Cmax) decreased by 15% to 39% and systemic exposure (AUC) decreased by 37% to 42% compared to administration in the fasting state.

MANAGEMENT: Migalastat should be taken on an empty stomach. Patients should avoid eating for at least 2 hours before and 2 hours after taking migalastat to give a minimum 4 hours fast. Clear liquids can be consumed during this 4-hour period.

References:

Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
"Product Information. Galafold (migalastat)." Amicus Therapeutics U.S., Inc., Cranbury, NJ.

Galafold

Generic Name: migalastat

Brand Name: Galafold

Synonyms: n.a.

What is Galafold?