Gattex and Food

Teduglutide may increase the absorption of any oral medication that you are taking. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Teduglutide has the potential to increase absorption of concomitantly administered oral medications. Altered mental status in association with teduglutide treatment has been observed in patients on benzodiazepines in clinical trials. In one case, a patient who received prazepam with teduglutide 0.05 mg/kg/day experienced dramatic deterioration in mental status progressing to coma during her first week of teduglutide therapy. She was admitted to the intensive care unit, where her benzodiazepine level was found to exceed 300 mcg/L. Both medications were discontinued, and the coma resolved five days later.

MANAGEMENT: Careful monitoring and possible dosage adjustment of oral medications that require titration or have a narrow therapeutic index are recommended during coadministration with teduglutide.