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Lorazepam Oral Concentrate and Obesity

Result of checking the interaction of Lorazepam Oral Concentrate and Obesity for safety when used together.

Check result:
Lorazepam Oral Concentrate <> Obesity
Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.

Professional:

The plasma half-lives of benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat. Marked increases in distribution (> 100%) have been reported for diazepam and midazolam, and moderate increases (25% to 100%) for alprazolam, lorazepam, and oxazepam. Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid toxicity.

References:
  • "Product Information. Tranxene (clorazepate)." Abbott Pharmaceutical, Abbott Park, IL.
  • "Product Information. Librium (chlordiazepoxide)." Roche Laboratories, Nutley, NJ.
  • "Product Information. Ativan (lorazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  • "Product Information. Serax (oxazepam)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  • "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
  • "Product Information. Klonopin (clonazepam)." Roche Laboratories, Nutley, NJ.
  • "Product Information. Restoril (temazepam)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
  • "Product Information. ProSom (estazolam)." Abbott Pharmaceutical, Abbott Park, IL.
  • "Product Information. Valium (diazepam)." Roche Laboratories, Nutley, NJ.
  • "Product Information. Xanax (alprazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
  • "Product Information. Versed (midazolam)." Roche Laboratories, Nutley, NJ.
  • "Product Information. Doral (quazepam)." Wallace Laboratories, Cranbury, NJ.
  • "Product Information. Dalmane (flurazepam)." Roche Laboratories, Nutley, NJ.
  • American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
Lorazepam Oral Concentrate

Generic Name: lorazepam

Brand Name: Ativan, Lorazepam Intensol

Synonyms: Lorazepam, LORazepam

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