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Pentamidine Injection and High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Result of checking the interaction of Pentamidine Injection and High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia) for safety when used together.

Check result:
Pentamidine Injection <> High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Acute and potentially fatal pancreatitis has been reported with parenteral use and, rarely, oral inhalation of pentamidine. Patients with a history of or known risk factors for pancreatitis, such as alcohol abuse or hypertriglyceridemia, should be monitored closely during therapy with pentamidine. Therapy should be discontinued at the first signs or symptoms suggestive of pancreatitis (e.g., nausea, vomiting, abdominal pain, hyperamylasemia with dysglycemia, rising triglycerides, decreasing serum calcium), and preferably permanently discontinued if clinical pancreatitis develops.

Professional:

Acute and potentially fatal pancreatitis has been reported with parenteral use and, rarely, oral inhalation of pentamidine. Patients with a history of or known risk factors for pancreatitis, such as alcohol abuse or hypertriglyceridemia, should be monitored closely during therapy with pentamidine. Therapy should be discontinued at the first signs or symptoms suggestive of pancreatitis (e.g., nausea, vomiting, abdominal pain, hyperamylasemia with dysglycemia, rising triglycerides, decreasing serum calcium), and preferably permanently discontinued if clinical pancreatitis develops.

References:
  • Klatt EC "Pathology of pentamidine-induced pancreatitis." Arch Pathol Lab Med 116 (1992): 162-4
  • Wood G, Wetzig N, Hogan P, Whitby M "Survival from pentamidine induced pancreatitis and diabetes mellitus." Aust N Z J Med 21 (1991): 341-2
  • Sauleda J, Gea JG, Aguar MC, Aran X, Pasto M, Broquetas JM "Probable pentamidine-induced acute pancreatitis." Ann Pharmacother 28 (1994): 52-3
  • Schwartz MS, Cappell MS "Pentamidine-associated pancreatitis." Dig Dis Sci 34 (1989): 1617-20
  • Tocci G, Alba L, D'Amato C, Grisetti S, Sampaolesi A, Visco GL "Pancreatitis associated with aerosolized pentamidine." Int Conf AIDS 9 (1993): 505
  • "Product Information. NebuPent (pentamidine)." Fujisawa, Deerfield, IL.
  • "Product Information. Pentam 300 (pentamidine)." Fujisawa, Deerfield, IL.
Pentamidine Injection

Generic Name: pentamidine

Brand Name: Nebupent, Pentam 300, Pentam

Synonyms: Pentamidine, Pentamidine (Oral Inhalation)

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