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Trametinib and Food

Result of checking the interaction of Trametinib and Food for safety when used together.

Check result:

Trametinib <> Food

Relevance: 03.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug interaction with food or lifestyle.

Consumer:

Food may delay and reduce the absorption of trametinib, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take trametinib at least 1 hour before or 2 hours after a meal.

Professional:

ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of trametinib. In study subjects, administration of a single dose of trametinib with a high-fat, high-calorie meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 70% and 24%, respectively, and delayed Tmax by approximately 4 hours compared to administration in the fasted state.

MANAGEMENT: Trametinib should be taken at least 1 hour before or 2 hours after a meal.

References: